Thromboelastography Reference Values for Third-Trimester Healthy Obstetric Patients in Northern Mexico.

Validation and clinical value of prognostic model for assessing the risk of severe acute pancreatitis based on inflammatory and hemostasis markers.

Thrombelastography and Conventional Coagulation Markers in Chronic Obstructive Pulmonary Disease: A Prospective Paired-Measurements Study Comparing Exacerbation and Stable Phases.

Viscoelastic testing (VET) has revolutionized modern coagulation management by offering rapid, real-time insights into the entire hemostatic process. By enabling precise, data-driven transfusion algorithms at the point of care, VET-guided strategies significantly improve patient blood management and clinical outcomes in high-stakes environments like trauma and cardiac surgery.

The TEG 5000 System: System Description and Protocol for Measurements.

"VETs assess dynamic aspects of hemostasis, regarding both clot formation and dissolution so allowing to evaluate a “dynamic” modification of hemostasis over time. They could provide to clinicians more information about the CAC, identifying at the patient bedside the presence of a hypercoagulable state and hypofibrinolysis, that are more evident than in coagulopathy during the sepsis. In regard to VTE prediction, the results of VETs analysis demonstrate a hypercoagulable state that is not predictive for thrombotic events in critically ill COVID-19 patients. The clinical application of VETs in patients with severe COVID-19 infection should be combined with biohumoral parameters (i.e. D-dimer). Future studies on large patient populations should define the usefulness of VETs as prognostic markers of micro- and macrothrombosis in severe COVID-19 patients to improve morbidity and mortality. The dynamic coagulative approach based on the use of VETs, associated to laboratory tests, might help to guide a personalized anticoagulant strategy, well knowing that “one size does not fit all”."

Comparison of assessment of coagulation in healthy dogs by the TEG 6s and TEG 5000 viscoelastic analyzers.

Thromboelastography-guided therapy improves patient blood management and certain clinical outcomes in elective cardiac and liver surgery and emergency resuscitation: A systematic review and analysis.

"Both TEG 5000-FLEV and TEG 6s-CFF correlated moderately with Clauss fibrinogen but decreased in correlation in both hyperfibrinogenemia and hypofibrinogenemia. Thus, we caution relying on TEG 5000 or TEG 6s to be the only laboratory measurement to guide fibrinogen replacement when resuscitating trauma patients at risk for TIC and TEG 5000-FLEV for assessing fibrinogen in patients with ESRD at risk for thrombotic events."

"Despite weaknesses in correlation and agreement both VET devices suggested appropriate coagulation management based on the simulated transfusion algorithms. Quantra and TEG-5000 are not interchangeable and none of them can be considered as "the gold standard"."

Agreement between the thromboelastography reaction time parameter using fresh and citrated whole blood during extracorporeal membrane oxygenation with Teg®5000 and Teg®6s.

Diagnostic Agreement Between TEG5000 and TEG6S in the Assessment of Hemostasis in Pediatric Cardiac Surgery: A Prospective Non-inferiority Study.

Sensitivity and specificity of thromboelastography for hyperfibrinolysis: Comparison of TEG 5000 and TEG 6S CK LY30 systems.

Viscoelastic coagulation testing in Neonatal Intensive Care Units: advantages and pitfalls in clinical practice.

Modern cartridge-based VET - specifically the TEG 6s, HemoSonics Quantra, and ROTEM sigma - offers superior portability and ease of use compared to traditional laboratory methods. Despite limited randomized evidence for these new-generation devices, VET-guided algorithms effectively reduce blood product usage without compromising patient outcomes. Future validation of clinical cut-offs will be key to optimizing transfusion management.

Comparison of Thromboelastography Devices TEG®6S Point of Care Device vs. TEG®5000 in Pediatric Patients Undergoing Cardiac Surgery.

Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices.

TEG® and ROTEM® Traces: Clinical Applications of Viscoelastic Coagulation Monitoring in Neonatal Intensive Care Unit.

"Strong correlations were observed between quantra parameters FCS and PCS with Clauss Fibrinogen and Platelet count. While Performance from ROC curves for predicted thrombocytopenia <150k platelet/µL is similar with TEG-5000, they are better for predicted fibrinogen concentration and prolonged aPTT."

Predictive accuracy of diagnostic tests for excessive bleeding in cardiac surgery: The COPTIC-C study.